Symptoms reported after mass drug administration for lymphatic filariasis in Leogane, Haiti.
Identifieur interne : 007837 ( Main/Exploration ); précédent : 007836; suivant : 007838Symptoms reported after mass drug administration for lymphatic filariasis in Leogane, Haiti.
Auteurs : Natasha Hochberg [États-Unis] ; Marie C. Michel ; Patrick J. Lammie ; Els Mathieu ; Abdel N. Direny ; Madsen Beau De Rochars ; David G. AddissSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 2006.
Descripteurs français
- KwdFr :
- Antihelminthiques (administration et posologie), Antihelminthiques (effets indésirables), Antihelminthiques (usage thérapeutique), Antihelminthiques (économie), Calendrier d'administration des médicaments, Femelle, Filariose lymphatique (), Filariose lymphatique (physiopathologie), Filariose lymphatique (traitement médicamenteux), Haïti, Humains, Mâle, Résultat thérapeutique, Évaluation de programme.
- MESH :
- administration et posologie : Antihelminthiques.
- effets indésirables : Antihelminthiques.
- physiopathologie : Filariose lymphatique.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Antihelminthiques.
- économie : Antihelminthiques.
- Calendrier d'administration des médicaments, Femelle, Filariose lymphatique, Haïti, Humains, Mâle, Résultat thérapeutique, Évaluation de programme.
- Wicri :
- geographic : Haïti.
English descriptors
- KwdEn :
- Anthelmintics (administration & dosage), Anthelmintics (adverse effects), Anthelmintics (economics), Anthelmintics (therapeutic use), Drug Administration Schedule, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (physiopathology), Elephantiasis, Filarial (prevention & control), Female, Haiti, Humans, Male, Program Evaluation, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Anthelmintics.
- chemical , adverse effects : Anthelmintics.
- chemical , economics : Anthelmintics.
- chemical , therapeutic use : Anthelmintics.
- geographic : Haiti.
- drug therapy : Elephantiasis, Filarial.
- physiopathology : Elephantiasis, Filarial.
- prevention & control : Elephantiasis, Filarial.
- Drug Administration Schedule, Female, Humans, Male, Program Evaluation, Treatment Outcome.
Abstract
Mass drug administration (MDA) for lymphatic filariasis (LF) can cause adverse reactions from microfilarial and adult worm death. Symptoms after the fifth annual MDA in Leogane, Haiti, were studied to determine whether they resulted from parasite death. Persons reporting post-MDA systemic symptoms at 5 of 148 drug distribution posts and men reporting scrotal pain at any post were interviewed. Participants were tested with immunochromatographic tests (ICTs), and men with scrotal symptoms were examined. At the five posts, 3,781 persons took anti-filarial medication. Of these, 314 (8%) returned with symptoms; the most common were headache (36%) and gastrointestinal complaints (28%). Of the 294 (94%) who consented to ICT testing, 47 (16%) were positive. Of 69 men with scrotal symptoms who consented to ICT testing, 18 (26.1%) were positive. After Leogane's fifth MDA, most symptomatic persons had undetectable levels of filarial antigen by ICT. Free symptomatic treatment may motivate some people to report symptoms and seek care.
PubMed: 17123989
Affiliations:
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Le document en format XML
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Michel</name></author><author><name sortKey="Lammie, Patrick J" sort="Lammie, Patrick J" uniqKey="Lammie P" first="Patrick J" last="Lammie">Patrick J. Lammie</name></author><author><name sortKey="Mathieu, Els" sort="Mathieu, Els" uniqKey="Mathieu E" first="Els" last="Mathieu">Els Mathieu</name></author><author><name sortKey="Direny, Abdel N" sort="Direny, Abdel N" uniqKey="Direny A" first="Abdel N" last="Direny">Abdel N. Direny</name></author><author><name sortKey="De Rochars, Madsen Beau" sort="De Rochars, Madsen Beau" uniqKey="De Rochars M" first="Madsen Beau" last="De Rochars">Madsen Beau De Rochars</name></author><author><name sortKey="Addiss, David G" sort="Addiss, David G" uniqKey="Addiss D" first="David G" last="Addiss">David G. 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Symptoms after the fifth annual MDA in Leogane, Haiti, were studied to determine whether they resulted from parasite death. Persons reporting post-MDA systemic symptoms at 5 of 148 drug distribution posts and men reporting scrotal pain at any post were interviewed. Participants were tested with immunochromatographic tests (ICTs), and men with scrotal symptoms were examined. At the five posts, 3,781 persons took anti-filarial medication. Of these, 314 (8%) returned with symptoms; the most common were headache (36%) and gastrointestinal complaints (28%). Of the 294 (94%) who consented to ICT testing, 47 (16%) were positive. Of 69 men with scrotal symptoms who consented to ICT testing, 18 (26.1%) were positive. After Leogane's fifth MDA, most symptomatic persons had undetectable levels of filarial antigen by ICT. Free symptomatic treatment may motivate some people to report symptoms and seek care.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Addiss, David G" sort="Addiss, David G" uniqKey="Addiss D" first="David G" last="Addiss">David G. Addiss</name><name sortKey="De Rochars, Madsen Beau" sort="De Rochars, Madsen Beau" uniqKey="De Rochars M" first="Madsen Beau" last="De Rochars">Madsen Beau De Rochars</name><name sortKey="Direny, Abdel N" sort="Direny, Abdel N" uniqKey="Direny A" first="Abdel N" last="Direny">Abdel N. Direny</name><name sortKey="Lammie, Patrick J" sort="Lammie, Patrick J" uniqKey="Lammie P" first="Patrick J" last="Lammie">Patrick J. Lammie</name><name sortKey="Mathieu, Els" sort="Mathieu, Els" uniqKey="Mathieu E" first="Els" last="Mathieu">Els Mathieu</name><name sortKey="Michel, Marie C" sort="Michel, Marie C" uniqKey="Michel M" first="Marie C" last="Michel">Marie C. Michel</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Hochberg, Natasha" sort="Hochberg, Natasha" uniqKey="Hochberg N" first="Natasha" last="Hochberg">Natasha Hochberg</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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